At a glance
NIH Director's Transformative Research Award (R01 Clinical Trial Optional) is a federal competitive grant from National Institutes of Health for the science & technology sector. Eligible applicants: State governments; Independent school districts; Small businesses; County governments; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education;. Applications are accepted on a rolling basis. Apply via the official listing at www.grants.gov.
- Amount
- See listing
- Deadline
- Rolling
- Type
- Competitive
- Status
- Forecasted
About this program
The NIH Director's Transformative Research Award supports individual scientists and research teams pursuing bold, groundbreaking, and unconventional research with the potential to transform science, create new scientific paradigms, establish new clinical approaches, or develop transformative technologies. The Transformative Research Award is part of the NIH Common Fund's High-Risk, High-Reward Research Program.
Who can apply
State governments; Independent school districts; Small businesses; County governments; Native American tribal organizations (other than Federally recognized tribal governments); Private institutions of higher education; City or township governments; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Native American tribal governments (Federally recognized); Others (see text field entitled "Additional Information on Eligibility" for clarification); Public and State controlled institutions of higher education; Public housing authorities/Indian housing authorities; Special district governments; For profit organizations other than small businesses. Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
How to apply
Apply through Grants.gov using funding opportunity number RFA-RM-28-003. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.
Apply at official sourceRelated grants
- RESTORE Act Direct Component - Non-Construction Activities USDOT · Up to $120.2M · Oct 31, 2027 Open
- FY 2026 - 2028 Broad Agency Announcement (BAA), National Ocean Service DOC · Up to $100 · Sep 30, 2028 Open
- Landscape Scale Restoration Grant Program for Tribes USDA · $100K–$300K · Jan 26, 2027 Open
- FY 2027 Crash Causal Factors Program DOT · $25K–$500K · Dec 28, 2026 Open