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Federal Forecasted GRANTS-GOV-351059

Integrating Machine Learning with Computational Fluid Dynamics Models of Orally Inhaled Drug Products (U01) Clinical Trials Not Allowed

Food and Drug Administration (HHS) · Competitive grant · Science & Technology

At a glance

Integrating Machine Learning with Computational Fluid Dynamics Models of Orally Inhaled Drug Products (U01) Clinical Trials Not Allowed is a federal competitive grant from Food and Drug Administration for the science & technology sector. Funding: $600K total. Eligible applicants: State governments; Public housing authorities/Indian housing authorities; Special district governments; Native American tribal governments (Federally recognized); County governments; City or township governments; Native. Applications are accepted on a rolling basis. Apply via the official listing at www.grants.gov.

Amount
$600K total
Deadline
Rolling
Type
Competitive
Status
Forecasted

About this program

Computational fluid dynamics (CFD) has played a crucial role in providing an alternative bioequivalence (BE) approach for generic orally inhaled drug products (OIDPs), in addition to comparative clinical endpoint or pharmacodynamic BE studies, as a relatively cost- and time-efficient complement to benchtop and clinical experiments that has been widely used in developing and assessing generic inhaler devices. However, despite the advances in the power of modern computers, there are still some bottlenecks in using CFD due to computational time, limited grid resolution, pre- and post-processing of large simulation data sets, model parameter estimations, and uncertainty quantifications. Machine learning (ML) has been gaining more attention as a potential tool to alleviate such limitations that arise in CFD. The purpose of this grant is to develop a methodology to integrate ML with CFD models of OIDPs to promote alternative BE studies to enhance and accelerate the development and approval of generic OIDPs.

Who can apply

State governments; Public housing authorities/Indian housing authorities; Special district governments; Native American tribal governments (Federally recognized); County governments; City or township governments; Native American tribal organizations (other than Federally recognized tribal governments); For profit organizations other than small businesses; Small businesses; Public and State controlled institutions of higher education; Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education; Private institutions of higher education; Independent school districts; Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education

How to apply

Apply through Grants.gov using funding opportunity number FOR-FD-24-001. Register your organization (SAM.gov + Grants.gov) before the deadline, then submit the application package listed in the official notice.

Apply at official source